In-line monitoring of cocrystallization process and quantification of carbamazepine-nicotinamide cocrystal using Raman spectroscopy and chemometric tools.

@article{Soares2017InlineMO,
  title={In-line monitoring of cocrystallization process and quantification of carbamazepine-nicotinamide cocrystal using Raman spectroscopy and chemometric tools.},
  author={Frederico Luis Felipe Soares and Renato Lajarim Carneiro},
  journal={Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy},
  year={2017},
  volume={180},
  pages={
          1-8
        }
}
  • Frederico Luis Felipe Soares, Renato Lajarim Carneiro
  • Published in
    Spectrochimica acta. Part A…
    2017
  • Chemistry, Medicine
  • A cocrystallization process may involve several molecular species, which are generally solid under ambient conditions. Thus, accurate monitoring of different components that might appear during the reaction is necessary, as well as quantification of the final product. This work reports for the first time the synthesis of carbamazepine-nicotinamide cocrystal in aqueous media with a full conversion. The reactions were monitored by Raman spectroscopy coupled with Multivariate Curve Resolution… CONTINUE READING

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