In-line monitoring of a pharmaceutical blending process using FT-Raman spectroscopy.

  title={In-line monitoring of a pharmaceutical blending process using FT-Raman spectroscopy.},
  author={Geert J Vergote and Thomas R De Beer and Chris Vervaet and Jean Paul Remon and W. R. G. Baeyens and N Diericx and Francis Verpoort},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  volume={21 4},
FT-Raman spectroscopy (in combination with a fibre optic probe) was evaluated as an in-line tool to monitor a blending process of diltiazem hydrochloride pellets and paraffinic wax beads. The mean square of differences (MSD) between two consecutive spectra was used to identify the time required to obtain a homogeneous mixture. A traditional end-sampling thief probe was used to collect samples, followed by HPLC analysis to verify the Raman data. Large variations were seen in the FT-Raman spectra… CONTINUE READING


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