In-line Size Monitoring of a Twin Screw Granulation Process Using High-Speed Imaging

  title={In-line Size Monitoring of a Twin Screw Granulation Process Using High-Speed Imaging},
  author={Arwa S. El Hagrasy and Paul Cruise and Ian Jones and James D. Litster},
  journal={Journal of Pharmaceutical Innovation},
This study aimed to evaluate the feasibility of implementing a 3D high-speed imaging camera for in-line monitoring of a continuous wet granulation process and its potential for real-time process control. The EyeconTM camera was used for monitoring a twin screw granulated-placebo formulation composed of lactose (73.5 %), microcrystalline cellulose (20 %), hydroxypropylmethyl cellulose (5 %), and croscarmellose sodium (1.5 %). Water was used as the granulating liquid at liquid-to-solid (L/S… CONTINUE READING
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Twin screw wet granulation: influence of formulation parameters on granule properties and growth behavior

  • A El Hagrasy, J Hennenkamp, M Burke, J Cartwright, J. Litster
  • Powder Technology
  • 2013
Highly Influential
4 Excerpts

Butterworth Heinemann; 2003

  • Oakland JS. Statistical process control. 5th ed. Burlington
  • 98 J Pharm Innov
  • 2013
Highly Influential
3 Excerpts

Powder sampling and particle size determination

  • T. Allen
  • 1st ed. Amsterdam: Elsevier;
  • 2003
Highly Influential
3 Excerpts

Twin screw granulation: granule properties

  • RM Dhenge, RS Fyles, JJ Cartwright, DG Doughty, MJ Hounslow, A. Salman
  • Chem Eng J. 2010;164:322–9
  • 2010

Validation of a continuous granulation process using a twin-screw extruder

  • BV Melkebeke, C Vervaet, JP. Remon
  • Int J Pharm
  • 2008

High shear granulation

  • GK Reynolds, PK Le, AM. Nilpawar
  • editors. Granulation. Handbook of powder…
  • 2007
1 Excerpt

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