In-line Size Monitoring of a Twin Screw Granulation Process Using High-Speed Imaging

@article{Hagrasy2013InlineSM,
  title={In-line Size Monitoring of a Twin Screw Granulation Process Using High-Speed Imaging},
  author={Arwa S. El Hagrasy and Paul Cruise and Ian Jones and James D. Litster},
  journal={Journal of Pharmaceutical Innovation},
  year={2013},
  volume={8},
  pages={90-98}
}
This study aimed to evaluate the feasibility of implementing a 3D high-speed imaging camera for in-line monitoring of a continuous wet granulation process and its potential for real-time process control. The EyeconTM camera was used for monitoring a twin screw granulated-placebo formulation composed of lactose (73.5 %), microcrystalline cellulose (20 %), hydroxypropylmethyl cellulose (5 %), and croscarmellose sodium (1.5 %). Water was used as the granulating liquid at liquid-to-solid (L/S… CONTINUE READING
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