In hyperthyroid rats octylguanidine protects the heart from reperfusion damage

@article{Pavn2008InHR,
  title={In hyperthyroid rats octylguanidine protects the heart from reperfusion damage},
  author={Natalia Pav{\'o}n and Alberto Aranda and Noem{\'i} Garc{\'i}a and Luz Hern{\'a}ndez‐Esquivel and Edmundo Ch{\'a}vez},
  journal={Endocrine},
  year={2008},
  volume={35},
  pages={158-165}
}
Hyperthyroidism sensitizes the heart for reperfusion injury. As known, mitochondrial permeability transition underlies reperfusion heart damage. This study was undertaken to explore the protective effect of octylguanidine (OG), an inhibitor of permeability transition, on hearts from hyperthyroid rats subjected to ischemia/reperfusion. Hyperthyroidism was induced by a daily injection of 2 mg T3/kg body weight for 5 days. OG was injected at a dose of 5 mg/kg body weight. It was found that the… Expand
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