In human keratinocytes the Common Deletion reflects donor variabilities rather than chronologic aging and can be induced by ultraviolet A irradiation.

@article{Koch2001InHK,
  title={In human keratinocytes the Common Deletion reflects donor variabilities rather than chronologic aging and can be induced by ultraviolet A irradiation.},
  author={Hartmut Koch and K. P. Wittern and J{\"o}rg Bergemann},
  journal={The Journal of investigative dermatology},
  year={2001},
  volume={117 4},
  pages={892-7}
}
Mitochondrial DNA mutations play a major role in human aging processes and degenerative diseases. The most frequently reported marker for mutations of the mitochondrial DNA in human skin is a 4977 bp large-scale deletion, called the Common Deletion. Although this deletion is rarely detectable and constitutes only one example of the multitude of about 50,000 known mutations in mitochondrial DNA, it can represent "the tip of the iceberg" of all types of mitochondrial DNA mutations. We established… CONTINUE READING

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