In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitment.

@article{Durali2003InHB,
  title={In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitment.},
  author={Deniz Durali and Marie-Ghislaine de Go{\"e}r de Herve and Julien Giron-Michel and Bruno Azzarone and J F Delfraissy and Yassine Taoufik},
  journal={Blood},
  year={2003},
  volume={102 12},
  pages={4084-9}
}
Two functionally distinct subsets of B cells that produce Th1- and Th2-like patterns of cytokines have recently been identified. Interleukin-12 (IL-12) is a critical immunoregulatory cytokine that promotes Th1 differentiation through activation of signal transducer and activator of transcription 4 (STAT4). IL-12 has been reported to induce interferon gamma (IFN-gamma) production in B cells, but the relevant signaling pathways are poorly documented. Here, in human primary B cells, we found a… CONTINUE READING
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