In hamsters the D1 receptor antagonist SCH23390 depresses ventilation during hypoxia.

@article{Schlenker2008InHT,
  title={In hamsters the D1 receptor antagonist SCH23390 depresses ventilation during hypoxia.},
  author={Evelyn Heymann Schlenker},
  journal={Brain research},
  year={2008},
  volume={1187},
  pages={146-53}
}
During exposure of animals to hypoxia, brain and blood dopamine levels increase stimulating dopaminergic receptors which influence the integrated ventilatory response to low oxygen. The purpose of the present study is to test the hypothesis that in conscious hamsters, systemic antagonism of D(1) receptors would depress their breathing in air and in response to hypoxic and hypercapnic challenges. Nine male hamsters were treated with saline or 0.25 mg/kg SCH-23390 (SCH), a D(1) receptor… CONTINUE READING

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