In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication

@article{Baltus2006InGC,
  title={In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication},
  author={Andrew E. Baltus and Douglas B Menke and Yueh-Chiang Hu and Mary L. Goodheart and Anne E. Carpenter and Dirk G. de Rooij and David C. Page},
  journal={Nature Genetics},
  year={2006},
  volume={38},
  pages={1430-1434}
}
The transition from mitosis to meiosis is a defining juncture in the life cycle of sexually reproducing organisms. In yeast, the decision to enter meiosis is made before the single round of DNA replication that precedes the two meiotic divisions. We present genetic evidence of an analogous decision point in the germ line of a multicellular organism. The mouse Stra8 gene is expressed in germ cells of embryonic ovaries, where meiosis is initiated, but not in those of embryonic testes, where… CONTINUE READING
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