In exponentially growing Saccharomyces cerevisiae cells, rRNA synthesis is determined by the summed RNA polymerase I loading rate rather than by the number of active genes.

@article{French2003InEG,
  title={In exponentially growing Saccharomyces cerevisiae cells, rRNA synthesis is determined by the summed RNA polymerase I loading rate rather than by the number of active genes.},
  author={Sarah L. French and Yvonne N. Osheim and Francesco Cioci and Masayasu Nomura and A. L. Beyer},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 5},
  pages={1558-68}
}
Genes encoding rRNA are multicopy and thus could be regulated by changing the number of active genes or by changing the transcription rate per gene. We tested the hypothesis that the number of open genes is limiting rRNA synthesis by using an electron microscopy method that allows direct counting of the number of active genes per nucleolus and the number of polymerases per active gene. Two strains of Saccharomyces cerevisiae were analyzed during exponential growth: a control strain with a… CONTINUE READING

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