In disperse solution, "osmotic stress" is a restricted case of preferential interactions.

  title={In disperse solution, "osmotic stress" is a restricted case of preferential interactions.},
  author={Serge N Timasheff},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 13},
  • Serge N Timasheff
  • Published 1998 in
    Proceedings of the National Academy of Sciences…
In the practice of "osmotic stress," the effect of excluded cosolvents on a biochemical equilibrium is interpreted as the number of water molecules participating in the reaction. This action is attributed to lowering of solvent water activity by the cosolvent. This concept of osmotic stress in disperse solution is erroneous: (i) A cosolvent cannot be both excluded and inert, i.e., noninteracting, because exclusion requires a positive free energy change; (ii) a decrease in water activity alone… CONTINUE READING

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