In depth comparison of an individual’s DNA and its lymphoblastoid cell line using whole genome sequencing

@inproceedings{Nickles2011InDC,
  title={In depth comparison of an individual’s DNA and its lymphoblastoid cell line using whole genome sequencing},
  author={Dorothee Nickles and Lohith Madireddy and Shan Chien Yang and Pouya Khankhanian and Steve Lincoln and Stephen L. Hauser and Jorge Oksenberg and Sergio E Baranzini},
  booktitle={BMC Genomics},
  year={2011}
}
BackgroundA detailed analysis of whole genomes can be now achieved with next generation sequencing. Epstein Barr Virus (EBV) transformation is a widely used strategy in clinical research to obtain an unlimited source of a subject’s DNA. Although the mechanism of transformation and immortalization by EBV is relatively well known at the transcriptional and proteomic level, the genetic consequences of EBV transformation are less well understood. A detailed analysis of the genetic alterations… CONTINUE READING

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