In contrast to effector T cells, CD4+CD25+FoxP3+ regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death.

@article{Fritzsching2005InCT,
  title={In contrast to effector T cells, CD4+CD25+FoxP3+ regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death.},
  author={Benedikt Fritzsching and Nina Oberle and Nadine Eberhardt and Sabine Quick and Johannes Maria de Haas and Brigitte T. Wildemann and Peter Heinrich Krammer and Elisabeth Suri-Payer},
  journal={Journal of immunology},
  year={2005},
  volume={175 1},
  pages={
          32-6
        }
}
CD4(+)CD25(+)FoxP3(+) regulatory T cells (T(reg)) suppress T cell function and protect rodents from autoimmune disease. Regulation of T(reg) during an immune response is of major importance. Enhanced survival of T(reg) is beneficial in autoimmune disease, whereas increased depletion by apoptosis is advantageous in cancer. We show here that freshly isolated FACS-sorted T(reg) are highly sensitive toward CD95-mediated apoptosis, whereas other T cell populations are resistant to CD95-induced… CONTINUE READING

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