In congenital hypothyroidism, an initial L-thyroxine dose of 10-12 μg/kg/day is sufficient and sometimes excessive based on thyroid tests 1 month later.

@article{Vaidyanathan2012InCH,
  title={In congenital hypothyroidism, an initial L-thyroxine dose of 10-12 μg/kg/day is sufficient and sometimes excessive based on thyroid tests 1 month later.},
  author={P. R. Vaidyanathan and Meenal Ravindra Pathak and Paul B. Kaplowitz},
  journal={Journal of pediatric endocrinology & metabolism : JPEM},
  year={2012},
  volume={25 9-10},
  pages={849-52}
}
BACKGROUND Current guidelines recommend an initial L-thyroxine (L-T4) dose of 10-15 μg/kg/day for the treatment of congenital hypothyroidism (CH). We analyzed our data for the treatment outcome at 1 month after we noted a frequent overtreatment even at the lower end of this dose range. METHODS A 3-year chart review of 55 patients with confirmed CH was… CONTINUE READING