In chronic nephropathies prolonged ACE inhibition can induce remission: dynamics of time-dependent changes in GFR. Investigators of the GISEN Group. Gruppo Italiano Studi Epidemiologici in Nefrologia.

@article{Ruggenenti1999InCN,
  title={In chronic nephropathies prolonged ACE inhibition can induce remission: dynamics of time-dependent changes in GFR. Investigators of the GISEN Group. Gruppo Italiano Studi Epidemiologici in Nefrologia.},
  author={Piero Ruggenenti and Annalisa Perna and Ruba Benini and Tullio Bertani and Carmine Zoccali and Quirino Maggiore and Maurizio Salvadori and Giuseppe Remuzzi},
  journal={Journal of the American Society of Nephrology : JASN},
  year={1999},
  volume={10 5},
  pages={997-1006}
}
The Ramipril Efficacy in Nephropathy Core and Follow-Up Study found that > or =36 mo of continued ramipril therapy decreased substantially the risk of end-stage renal failure (ESRF) in patients with chronic nephropathies and a urinary protein excretion rate > or =3 g/24 h. This study investigates the time-dependent changes in GFR in these patients and in control subjects who were randomized to conventional therapy during the Core period and switched to ramipril during the Follow-Up study… CONTINUE READING

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