In-cell selectivity profiling of membrane-anchored and replicase-associated hepatitis C virus NS3-4A protease reveals a common, stringent substrate recognition profile.

Abstract

The need to identify anti-Flaviviridae agents has resulted in intensive biochemical study of recombinant nonstructural (NS) viral proteases; however, experimentation on viral protease-associated replication complexes in host cells is extremely challenging and therefore limited. It remains to be determined if membrane anchoring and/or association to… (More)
DOI: 10.1515/BC.2011.076

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@article{Martin2011IncellSP, title={In-cell selectivity profiling of membrane-anchored and replicase-associated hepatitis C virus NS3-4A protease reveals a common, stringent substrate recognition profile.}, author={Morgan M Martin and Stephanie A Condotta and Jeremy Fenn and Andrea D. Olmstead and F. Jean}, journal={Biological chemistry}, year={2011}, volume={392 10}, pages={927-35} }