In breast cancer, a high ratio of tumour-infiltrating intraepithelial CD8+ to FoxP3+ cells is characteristic for the medullary subtype.

@article{Anz2011InBC,
  title={In breast cancer, a high ratio of tumour-infiltrating intraepithelial CD8+ to FoxP3+ cells is characteristic for the medullary subtype.},
  author={David Anz and Stephan Eiber and Christoph Scholz and Stefan C. Endres and Thomas W. Kirchner and Carole Bourquin and Doris Mayr},
  journal={Histopathology},
  year={2011},
  volume={59 5},
  pages={965-74}
}
AIMS Medullary breast cancer (MBC) is a biologically distinct subtype of breast cancer characterized by prominent lymphocytic infiltrates and a favourable clinical outcome. Tumour-infiltrating CD8+ effector T cells may contribute to the good prognosis of this type of cancer; however, certain subtypes of lymphocyte, such as FoxP3+ regulatory T cells (Tregs), can also suppress antitumour immunity. METHODS AND RESULTS We determined tumour infiltration by FoxP3+, CCL22+ and CD8+ cells in paraffin… CONTINUE READING

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