In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation.

@article{Weinger2008InBA,
  title={In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation.},
  author={Jason G. Weinger and Pouyan Gohari and Ying Jun Yan and Jonathan M. Backer and Brian Varnum and Bridget Shafit-Zagardo},
  journal={Journal of neurochemistry},
  year={2008},
  volume={106 1},
  pages={134-46}
}
Axl is a receptor tyrosine kinase implicated in cell survival following growth factor withdrawal and other stressors. The binding of Axl's ligand, growth arrest-specific protein 6 (Gas6), results in Axl autophosphorylation, recruitment of signaling molecules, and activation of downstream survival pathways. Pull-down assays and immunoprecipitations using wildtype and mutant Axl transfected cells determined that Axl directly binds growth factor receptor-bound protein 2 (Grb2) at pYVN and the p85… CONTINUE READING