In autoimmune hepatitis type 1 or the autoimmune hepatitis-sclerosing cholangitis variant defective regulatory T-cell responsiveness to IL-2 results in low IL-10 production and impaired suppression.

@article{Liberal2015InAH,
  title={In autoimmune hepatitis type 1 or the autoimmune hepatitis-sclerosing cholangitis variant defective regulatory T-cell responsiveness to IL-2 results in low IL-10 production and impaired suppression.},
  author={Rodrigo Liberal and Charlotte Grant and Beth Holder and John Cardone and Marc Mart{\'i}nez-Llordella and Yun Ma and Michael A. Heneghan and Giorgina Mieli-Vergani and Diego Vergani and Maria Serena Longhi},
  journal={Hepatology},
  year={2015},
  volume={62 3},
  pages={
          863-75
        }
}
UNLABELLED Defective immune regulation plays a permissive role enabling effector cells to initiate and perpetuate tissue damage, eventually resulting in autoimmune disease. Numerical and functional regulatory T-cell (Treg) impairment has been previously reported in autoimmune liver disease (AILD; including autoimmune hepatitis and autoimmune sclerosing cholangitis ASC). However, in these early reports, Tregs were phenotypically defined as CD4(+) CD25(+) or CD4(+) CD25(high) cells. In the… CONTINUE READING
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Impairment of CD4(+)CD25(+) regulatory T-cells in autoimmune liver disease.

Journal of hepatology • 2004
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