In anticipation of International Stroke Trial-3 (IST-3).

  title={In anticipation of International Stroke Trial-3 (IST-3).},
  author={Patrick D. Lyden},
  volume={43 6},
Few medical advances have polarized physicians so powerfully as thrombolytic therapy for stroke.1 After years of delays, this highly efficacious treatment fully entered mainstream clinical use with the publication of the European Cooperative Acute Stroke Study (ECASS)-3 study; annually we see increasing rates of use globally.2 Along the way, many self-appointed “expert critiques” challenged the original trials and sought to insinuate that the therapy was less effective than primary data… CONTINUE READING

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