In acute kidney injury, indoxyl sulfate impairs human endothelial progenitor cells: modulation by statin

@article{Wu2013InAK,
  title={In acute kidney injury, indoxyl sulfate impairs human endothelial progenitor cells: modulation by statin},
  author={Vin Cent Wu and G Young and P N Huang and S Lo and Kuo-Chuan Wang and C Sun and Chan-Jung Liang and Tao-Ming Huang and Jou-Han Chen and Fan-Chi Chang and Yuh-Lien Chen and Yih-Shing Kuo and J Chen and Jaw-Wen Chen and Yung-Ming Chen and Wen-Jo Ko and K D Wu},
  journal={Angiogenesis},
  year={2013},
  volume={16},
  pages={609-624}
}
Renal ischemia rapidly mobilizes endothelial progenitor cells (EPCs), which provides renoprotection in acute kidney injury (AKI). Indoxyl sulfate (IS) is a protein-binding uremic toxin with a potential role in endothelial injury. In this study, we examined the effects and mechanisms of action of IS on EPCs in AKI. Forty-one consecutive patients (26 male; age, 70.1 ± 14.1 years) diagnosed with AKI according to the AKIN criteria were enrolled. The AKI patients had higher serum IS levels than… CONTINUE READING
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