In a rat model of parkinsonism, lesions of the subthalamic nucleus reverse increases of reaction time but induce a dramatic premature responding deficit.

@article{Baunez1995InAR,
  title={In a rat model of parkinsonism, lesions of the subthalamic nucleus reverse increases of reaction time but induce a dramatic premature responding deficit.},
  author={Christelle Baunez and Andr{\'e} Nieoullon and Marianne Amalric},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1995},
  volume={15 10},
  pages={6531-41}
}
Lesions of the subthalamic nucleus (STN) have been found to reduce the severe akinetic motor symptom produced in animal models of Parkinson's disease, such as in monkeys treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or in monoamine-depleted rats. However, little is known about the effect of STN exclusion on subtle motor deficits induced by moderate dopaminergic lesions in complex motor tasks. The present study was thus performed on rats trained in a reaction time (RT) task… CONTINUE READING
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