In Vivo antimalarial activity of aqueous extracts from Kenyan medicinal plants and their Chloroquine (CQ) potentiation effects against a blood‐induced CQ‐resistant rodent parasite in mice

@article{Muregi2007InVA,
  title={In Vivo antimalarial activity of aqueous extracts from Kenyan medicinal plants and their Chloroquine (CQ) potentiation effects against a blood‐induced CQ‐resistant rodent parasite in mice},
  author={Francis W Muregi and Akira Ishih and Tohru Suzuki and Hideto Kino and Teruaki Amano and Gerald M. Mkoji and Toshio Miyase and Mamoru Terada},
  journal={Phytotherapy Research},
  year={2007},
  volume={21}
}
Hot water extracts from eight medicinal plants representing five families, used for malaria treatment in Kenya were screened for their in vivo antimalarial activity in mice against a chloroquine (CQ) resistant Plasmodium berghei NK65, either alone or in combination with CQ. Extracts of three plants, Toddalia asiatica (root bark), Rhamnus prinoides (leaves and root bark) and Vernonia lasiopus (root bark) showed high chemosuppression in the range 51%–75%. Maytenus acuminata, M. heterophylla, M… 
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Antifungal activity of crude extracts of selected medicinal plants used in combinations in Lake Victoria Basin, Kenya
TLDR
Findings in this study are a preliminary verification of the usefulness of using herbal plants in combinations as a prevalent practice among the traditional healers.
Antimalarial properties of crude extracts of seeds of Brucea antidysenterica and leaves of Ocimum lamiifolium
TLDR
Crude aqueous, methanol and chloroform extracts of the two medicinal plants possess acceptable antimalarial effects, and further investigation should be pursued on toxicity study and to isolate the bioactive components responsible for the observed antiplasmodial action of the plants.
Antiplasmodial and larvicidal compounds of Toddalia asiatica root bark
TLDR
Toddaculatin was the most active against chloroquine sensitive D6 strain of Plasmodium falciparum while toddanol was found to be toxic against Aedes aegyti 2nd instar larvae.
In Vivo Evaluation of Anti-Malarial Activity of Three Medicinal Plants Used in South Eastern Nigeria
Aqueous extracts of the stem bark, fruit pericarp, seeds, and leaves of Pentaclethra macrophylla Benth.; the leaves of Phyllanthus niruri L.; and the leaves of Euphorbia hirta L. were tested for…
In vitro Anti-plasmodial Activity of Rubia cordifolia, Harrizonia abyssinica, Leucas calostachys Olive and Sanchus schweinfurthii Medicinal Plants.
TLDR
In vitro anti-plasmodial activities of herbal drugs were analysed according to the methods of Tona et al., 1999 and Methanolic extracts were more efficacious than aqueous extracts.
Antimalarial activity of Cucumis metuliferus and Lippia kituiensis against Plasmodium berghei infection in mice
TLDR
It is reported that the two plants induced suppression which is equivalent to that induced by chloroquine (C. metuliferus chloroform and L. Kituiensis ethyl acetate), which has been demonstrated to be potential sources of antimalarial templates.
Evaluation of the combination of Uvaria chamae (P. Beauv.) and amodiaquine in murine malaria.
Plants as antimalarial agents in Sub-Saharan Africa.
In vivo antiplasmodial and toxicological effect of Maytenus senegalensis traditionally used in the treatment of malaria in Tanzania
TLDR
The displayed high in vivo antiplasmodial activity and lack of toxic effect render M. senegalensis a candidate for the bioassay-guided isolation of compounds which could develop into new lead structures and candidates for drug development programmes against human malaria.
Medicinal plants as a fight against murine blood-stage malaria
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