In Vivo UTE-MRI Reveals Positive Effects of Raloxifene on Skeletal-Bound Water in Skeletally Mature Beagle Dogs.

@article{Allen2015InVU,
  title={In Vivo UTE-MRI Reveals Positive Effects of Raloxifene on Skeletal-Bound Water in Skeletally Mature Beagle Dogs.},
  author={Matthew R Allen and Paul R Territo and Chung Jung Lin and Scott A Persohn and Lei Jiang and Amanda Riley and Brian P. McCarthy and Christopher L Newman and David B. Burr and Gary D. Hutchins},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2015},
  volume={30 8},
  pages={
          1441-4
        }
}
Raloxifene positively affects mechanical properties of the bone matrix in part through modification of skeletal-bound water. The goal of this study was to determine if raloxifene-induced alterations in skeletal hydration could be measured in vivo using ultra-short echotime magnetic resonance imaging (UTE-MRI). Twelve skeletally mature female beagle dogs (n = 6/group) were treated for 6 months with oral doses of saline vehicle (VEH, 1 mL/kg/d) or raloxifene (RAL, 0.5 mg/kg/d). After 6 months of… CONTINUE READING
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