In Vivo Suppression of MicroRNA-24 Prevents the Transition Toward Decompensated Hypertrophy in Aortic-Constricted Mice

@inproceedings{RongChangLi2013InVS,
  title={In Vivo Suppression of MicroRNA-24 Prevents the Transition Toward Decompensated Hypertrophy in Aortic-Constricted Mice},
  author={Rong-ChangLi and Jintao and Yun-BoGuo and Hao-DiWu and Rui-FengLiu and YanBai and Zhi-ZhenLv and Guan-ZhengLuo and Lin-LinLi and Mengwang and Hua-QianYang and Weigao and Qi-deHAN and You-yiZhang and Xiu-JieWang and Mingxu and Shi-QiangWang},
  year={2013}
}
Rationale:During the transition from compensated hypertrophy to heart failure, the signaling between L-type Ca2+ channels in the cell membrane/T-tubules and ryanodine receptors in the sarcoplasmic reticulum becomes defective, partially because of the decreased expression of a T-tubule–sarcoplasmic reticulum anchoring protein, junctophilin-2. MicroRNA (miR)-24, a junctophilin-2 suppressing miR, is upregulated in hypertrophied and failing cardiomyocytes. Objective:To test whether miR-24… CONTINUE READING

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