In Vivo SELEX of Single-Stranded Domains in the HIV-1 Leader RNA

  title={In Vivo SELEX of Single-Stranded Domains in the HIV-1 Leader RNA},
  author={Nikki van Bel and A. Das and B. Berkhout},
  journal={Journal of Virology},
  pages={1870 - 1880}
ABSTRACT The 5′ untranslated leader region of the human immunodeficiency virus type 1 (HIV-1) RNA genome is a strongly conserved sequence that encodes several regulatory motifs important for viral replication. Most of these motifs are exposed as hairpin structures, including the dimerization initiation signal (DIS), the major splice donor site (SD), and the packaging signal (Ψ), which are connected by short single-stranded regions. Mutational analysis revealed many functions of these hairpins… Expand
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