In Vivo Role of Neutrophil Extracellular Traps in Antiphospholipid Antibody-Mediated Venous Thrombosis.

@article{Meng2017InVR,
  title={In Vivo Role of Neutrophil Extracellular Traps in Antiphospholipid Antibody-Mediated Venous Thrombosis.},
  author={He Meng and Srilakshmi Yalavarthi and Yogendra Kanthi and Levi F. Mazza and Megan A Elfline and Catherine E Luke and David J. Pinsky and Peter K. Henke and Jason S. Knight},
  journal={Arthritis & rheumatology},
  year={2017},
  volume={69 3},
  pages={655-667}
}
OBJECTIVE Antiphospholipid syndrome (APS) is a leading acquired cause of thrombotic events. Although antiphospholipid antibodies have been shown to promote thrombosis in mice, the role of neutrophils has not been explicitly studied. The aim of this study was to characterize neutrophils in the context of a new model of antiphospholipid antibody-mediated venous thrombosis. METHODS Mice were administered fractions of IgG obtained from patients with APS. At the same time, blood flow through the… CONTINUE READING