In Vivo Reinsertion of Excised Episomes by the V(D)J Recombinase: A Potential Threat to Genomic Stability

@article{Vanura2007InVR,
  title={In Vivo Reinsertion of Excised Episomes by the V(D)J Recombinase: A Potential Threat to Genomic Stability},
  author={Katrina Vanura and Bertrand Montpellier and Trang T. H. Le and Salvatore Spicuglia and J. R. Marcos Navarro and Olivier Cabaud and Sandrine Roulland and Elodie Vachez and Immo Prinz and Pierre Ferrier and Rodrig Marculescu and Ulrich Dr Jaeger and Bertrand Nadel},
  journal={PLoS Biology},
  year={2007},
  volume={5},
  pages={5 - 11}
}
It has long been thought that signal joints, the byproducts of V(D)J recombination, are not involved in the dynamics of the rearrangement process. Evidence has now started to accumulate that this is not the case, and that signal joints play unsuspected roles in events that might compromise genomic integrity. Here we show both ex vivo and in vivo that the episomal circles excised during the normal process of receptor gene rearrangement may be reintegrated into the genome through trans-V(D)J… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 18 CITATIONS

The ESC: The Dangerous By-Product of V(D)J Recombination

VIEW 10 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Transpositionally active episomal hAT elements

  • BMC Molecular Biology
  • 2009
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

V(D)J Recombination: Mechanism, Errors, and Fidelity.

  • Microbiology spectrum
  • 2014
VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 63 REFERENCES

The role of LMO2 in development and in T cell leukemia after chromosomal translocation or retroviral insertion.

  • Molecular therapy : the journal of the American Society of Gene Therapy
  • 2006
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL