In Vivo Real-Time Control of Gene Expression: A Comparative Analysis of Feedback Control Strategies in Yeast.

@article{Fiore2016InVR,
  title={In Vivo Real-Time Control of Gene Expression: A Comparative Analysis of Feedback Control Strategies in Yeast.},
  author={Gianfranco Fiore and Giansimone Perrino and Mario di Bernardo and Diego di Bernardo},
  journal={ACS synthetic biology},
  year={2016},
  volume={5 2},
  pages={154-62}
}
Real-time automatic regulation of gene expression is a key technology for synthetic biology enabling, for example, synthetic circuit's components to operate in an optimal range. Computer-guided control of gene expression from a variety of inducible promoters has been only recently successfully demonstrated. Here we compared, in silico and in vivo, three different control algorithms: the Proportional-Integral (PI) and Model Predictive Control (MPC) controllers, which have already been used to… CONTINUE READING
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