In Vivo Quantification of Tumor Receptor Binding Potential with Dual-Reporter Molecular Imaging

  title={In Vivo Quantification of Tumor Receptor Binding Potential with Dual-Reporter Molecular Imaging},
  author={Kenneth M Tichauer and Kimberley S. Samkoe and Kristian J. Sexton and Shannon K. Hextrum and Harold H. Yang and W. Spencer Klubben and Jason R. Gunn and Tayyaba Hasan and Brian W. Pogue},
  journal={Molecular Imaging and Biology},
Receptor availability represents a key component of current cancer management. However, no approaches have been adopted to do this clinically, and the current standard of care is invasive tissue biopsy. A dual-reporter methodology capable of quantifying available receptor binding potential of tumors in vivo within a clinically relevant time scale is presented. To test the methodology, a fluorescence imaging-based adaptation was validated against ex vivo and in vitro measures of epidermal growth… CONTINUE READING


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