In Vivo Pulmonary Delivery and Magnetic-Targeting of Dry Powder Nano-in-Microparticles

@inproceedings{Price2017InVP,
  title={In Vivo Pulmonary Delivery and Magnetic-Targeting
of Dry Powder Nano-in-Microparticles},
  author={Dominique N. Price and Loreen R. Stromberg and Nitesh K Kunda and Pavan Muttil},
  booktitle={Molecular pharmaceutics},
  year={2017}
}
This brief communication evaluates the cytotoxicity and targeting capability of a dry powder chemotherapeutic. Nano-in-microparticles (NIMs) are a dry powder drug delivery vehicle containing superparamagnetic iron oxide nanoparticles (SPIONs) and either doxorubicin (w/w solids) or fluorescent nanospheres (w/v during formulation; as a drug surrogate) in a lactose matrix. In vitro cytotoxicity was evaluated in A549 adenocarcinoma cells using MTS and LDH assays to assess viability and toxicity… CONTINUE READING
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