In Vivo Protection of Nigral Dopamine Neurons by Lentiviral Gene Transfer of the Novel GDNF-Family Member Neublastin/Artemin

@article{Rosenblad2000In,
  title={
 In Vivo Protection of Nigral Dopamine Neurons by Lentiviral Gene Transfer of the Novel GDNF-Family Member Neublastin/Artemin},
  author={Carl Rosenblad and Mette Gr{\o}nborg and Claus Hansen and Nikolaj S. Blom and Morten Meyer and Jens Leander Johansen and Lone Dag{\o} and Deniz Kirik and Umesh A. Patel and Cecilia Lundberg and Didier Trono and Anders Bj{\"o}rklund and Teit Eliot Johansen},
  journal={Molecular and Cellular Neuroscience},
  year={2000},
  volume={15},
  pages={199-214}
}
The glial cell line-derived neurotrophic factor (GDNF)-family of neurotrophic factors consisted until recently of three members, GDNF, neurturin, and persephin. We describe here the cloning of a new GDNF-family member, neublastin (NBN), identical to artemin (ART), recently published (Baloh et al., 1998). Addition of NBN/ART to cultures of fetal mesencephalic dopamine (DA) neurons increased the number of surviving tyrosine hydroxylase (TH)-immunoreactive neurons by approximately 70%, similar to… 
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Long‐term striatal overexpression of GDNF selectively downregulates tyrosine hydroxylase in the intact nigrostriatal dopamine system
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