In Vivo Pretargeted Imaging of HER2 and TAG-72 Expression Using the HaloTag Enzyme

@inproceedings{Knight2017InVP,
  title={In Vivo Pretargeted Imaging of HER2 and TAG-72 Expression
Using the HaloTag Enzyme},
  author={James C Knight and Michael J. Mosley and H. Tetsuo Uyeda and Mei Cong and Frank C Fan and Stephen Faulkner and B. M. Cornelissen},
  booktitle={Molecular pharmaceutics},
  year={2017}
}
A novel pretargeted SPECT imaging strategy based on the HaloTag enzyme has been evaluated for the first time in a living system. To determine the efficacy of this approach, two clinically relevant cancer biomarkers, HER2 and TAG-72, were selected to represent models of internalizing and noninternalizing antigens, respectively. In MDA-MB-231/H2N (HER2-expressing) and LS174T (TAG-72-expressing) xenograft tumors in mice, pretargeting experiments were performed in which HaloTag-conjugated… CONTINUE READING
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