In Vivo Pharmacological Characterization of TAK-063 , a Potent and Selective Phosphodiesterase 10 A Inhibitor with Antipsychotic-Like Activity in Rodents s

@inproceedings{Suzuki2015InVP,
  title={In Vivo Pharmacological Characterization of TAK-063 , a Potent and Selective Phosphodiesterase 10 A Inhibitor with Antipsychotic-Like Activity in Rodents s},
  author={Kazunori Suzuki and Akina Harada and Eri Shiraishi and Haruhide Kimura},
  year={2015}
}
Phosphodiesterase 10A (PDE10A) is a cAMP/cGMP phosphodiesterase highly expressed in medium spiny neurons (MSNs) in the striatum. We evaluated the in vivo pharmacological profile of a potent and selective PDE10A inhibitor, TAK-063 (1-[2-fluoro-4(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one). TAK-063 at 0.3 and 1 mg/kg p.o… CONTINUE READING