In Vivo Pharmacokinetics of Bromfenac Ophthalmic Solution 0.075%, Bromfenac Ophthalmic Solution 0.07%, and Nepafenac/Amfenac Ophthalmic Suspension 0.3% in Rabbits

@article{Sheppard2018InVP,
  title={In Vivo Pharmacokinetics of Bromfenac Ophthalmic Solution 0.075%, Bromfenac Ophthalmic Solution 0.07%, and Nepafenac/Amfenac Ophthalmic Suspension 0.3% in Rabbits},
  author={J. Sheppard and P. Cockrum and A. Justice and Mark C Jasek},
  journal={Ophthalmology and Therapy},
  year={2018},
  volume={7},
  pages={157 - 165}
}
  • J. Sheppard, P. Cockrum, +1 author Mark C Jasek
  • Published 2018
  • Medicine
  • Ophthalmology and Therapy
  • IntroductionLittle is known of the ocular distribution characteristics of currently branded non-steroidal anti-inflammatory drugs (NSAIDs) in the United States. This study was designed to predict the ocular bioavailability characteristics in humans using Dutch Belted rabbits as a surrogate. Commercially available, topically-applied NSAIDs containing bromfenac or nepafenac/amfenac were evaluated.Methods126 healthy adult Dutch Belted rabbits were randomly assigned to three treatment cohorts… CONTINUE READING
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