In Vivo Neurochemical Characterization of Developing Guinea Pigs and the Effect of Chronic Fetal Hypoxia

@article{Wang2016InVN,
  title={In Vivo Neurochemical Characterization of Developing Guinea Pigs and the Effect of Chronic Fetal Hypoxia},
  author={Wenchong Wang and Phil Lee and Yafeng Dong and Hung-Wen Yeh and Jieun Kim and Carl P. Weiner and William M. Brooks and In-Young Choi},
  journal={Neurochemical Research},
  year={2016},
  volume={41},
  pages={1831-1843}
}
The guinea pig is a frequently used animal model for human pregnancy complications, such as oxygen deprivation or hypoxia, which result in altered brain development. To investigate the impact of in utero chronic hypoxia on brain development, pregnant guinea pigs underwent either normoxic or hypoxic conditions at about 70 % of 65-day term gestation. After delivery, neurochemical profiles consisting of 19 metabolites and macromolecules were obtained from the neonatal cortex, hippocampus, and… CONTINUE READING
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