In Vivo Methods for the Assessment of Topical Drug Bioavailability

  title={In Vivo Methods for the Assessment of Topical Drug Bioavailability},
  author={Christophe Herkenne and Ingo Alberti and Aarti C. Naik and Yogeshvar N Kalia and F. Mathy and V{\'e}ronique Pr{\'e}at and Richard Guy},
  journal={Pharmaceutical Research},
  pages={87 - 103}
This paper reviews some current methods for the in vivo assessment of local cutaneous bioavailability in humans after topical drug application. After an introduction discussing the importance of local drug bioavailability assessment and the limitations of model-based predictions, the focus turns to the relevance of experimental studies. The available techniques are then reviewed in detail, with particular emphasis on the tape stripping and microdialysis methodologies. Other less developed… CONTINUE READING


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