In Vivo Labeling of Brain Capillary Endothelial Cells after Intravenous Injection of Monoclonal Antibodies Targeting the Transferrin Receptor

@article{ParisRobidas2011InVL,
  title={In Vivo Labeling of Brain Capillary Endothelial Cells after Intravenous Injection of Monoclonal Antibodies Targeting the Transferrin Receptor},
  author={Sarah Paris-Robidas and V. {\'E}mond and Cyntia Tremblay and D. Soulet and F. Calon},
  journal={Molecular Pharmacology},
  year={2011},
  volume={80},
  pages={32 - 39}
}
  • Sarah Paris-Robidas, V. Émond, +2 authors F. Calon
  • Published 2011
  • Biology, Medicine
  • Molecular Pharmacology
  • The development of vectors for drug delivery to the central nervous system remains a major pharmaceutical challenge. Here, we have characterized the brain distribution of two monoclonal antibodies (MAbs) targeting the mouse transferrin receptor (TfR) (clones Ri7 and 8D3) compared with control IgGs after intravenous injection into mice. MAbs were fluorolabeled with either Alexa Fluor (AF) dyes 647 or 750. Intravenous injection of Ri7 or 8D3 MAb coupled with AF750 led to higher fluorescence… CONTINUE READING
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