In Vivo Inhibition of c-MYC in Myeloid Cells Impairs Tumor-Associated Macrophage Maturation and Pro-Tumoral Activities

@inproceedings{Pello2012InVI,
  title={In Vivo Inhibition of c-MYC in Myeloid Cells Impairs Tumor-Associated Macrophage Maturation and Pro-Tumoral Activities},
  author={Oscar M Pello and Raphael Ch{\`e}vre and Damya Laoui and Alba de Juan and Fidel Lolo and Mar{\'i}a Jes{\'u}s Andr{\'e}s-Manzano and Manuel Serrano and Jo A. van Ginderachter and Vicente Andr{\'e}s},
  booktitle={PloS one},
  year={2012}
}
Although tumor-associated macrophages (TAMs) are involved in tumor growth and metastasis, the mechanisms controlling their pro-tumoral activities remain largely unknown. The transcription factor c-MYC has been recently shown to regulate in vitro human macrophage polarization and be expressed in macrophages infiltrating human tumors. In this study, we exploited the predominant expression of LysM in myeloid cells to generate c-Myc(fl/fl) LysM(cre/+) mice, which lack c-Myc in macrophages, to… CONTINUE READING

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