In Vivo Induction of Anergy in Peripheral V 08 + T Cells by Staphylococcal Enterotoxin B By

We have developed a model of peripheral in vivo T cell tolerance that is induced by administration of the protein superantigen staphylococcal enterotoxin B (SEB). Rather than activating V08+ T cells, in vivo administration of SEB induced in them a profound state of anergy. This was shown by their failure to proliferate to subsequent in vitro restimulation… CONTINUE READING