In Vivo Imaging of Particle-Induced Inflammation and Osteolysis in the Calvariae of NFκB/Luciferase Transgenic Mice

@inproceedings{Takahashi2011,
  title={
					In Vivo Imaging of Particle-Induced Inflammation and Osteolysis in the Calvariae of NFκB/Luciferase Transgenic Mice},
  author={Kunihiko Takahashi and Shin Onodera and Harukazu Tohyama and Hyuck Joon Kwon and Ken-ichi Honma and Kazunori Yasuda},
  booktitle={Journal of biomedicine & biotechnology},
  year={2011}
}
Wear debris causes biological response which can result in periprosthetic osteolysis after total joint replacement surgery. Nuclear factor-kappa B (NFκB), a representative transcription factor involved in inflammation, is believed to play an important role in this event by regulating the production of proinflammatory mediators and osteoclastogenesis. In this study, we sought to determine whether activation of NFκB in response to stimulation by particles could be visualized by in vivo imaging… CONTINUE READING

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