In Vivo Human Apolipoprotein E Isoform Fractional Turnover Rates in the CNS

@inproceedings{Wildsmith2012InVH,
  title={In Vivo Human Apolipoprotein E Isoform Fractional Turnover Rates in the CNS},
  author={Kristin R. Wildsmith and Jacob Martin Basak and Bruce W. Patterson and Yuriy Pyatkivskyy and Jungsu Kim and Kevin E Yarasheski and Jennifer X. Wang and Kwasi G. Mawuenyega and Hong Jiang and Maia Parsadanian and Hyejin Yoon and Tom P Kasten and Wendy C. Sigurdson and Chengjie Xiong and Alison M. Goate and David M Holtzman and Randall J. Bateman},
  booktitle={PloS one},
  year={2012}
}
Apolipoprotein E (ApoE) is the strongest genetic risk factor for Alzheimer's disease and has been implicated in the risk for other neurological disorders. The three common ApoE isoforms (ApoE2, E3, and E4) each differ by a single amino acid, with ApoE4 increasing and ApoE2 decreasing the risk of Alzheimer's disease (AD). Both the isoform and amount of ApoE in the brain modulate AD pathology by altering the extent of amyloid beta (Aβ) peptide deposition. Therefore, quantifying ApoE isoform… CONTINUE READING
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