In Vivo Human Apolipoprotein E Isoform Fractional Turnover Rates in the CNS

  title={In Vivo Human Apolipoprotein E Isoform Fractional Turnover Rates in the CNS},
  author={Kristin R. Wildsmith and Jacob Martin Basak and Bruce W. Patterson and Yuriy Pyatkivskyy and Jungsu Kim and Kevin E Yarasheski and Jennifer X. Wang and Kwasi G. Mawuenyega and Hong Jiang and Maia Parsadanian and Hyejin Yoon and Tom P Kasten and Wendy C. Sigurdson and Chengjie Xiong and Alison M. Goate and David M Holtzman and Randall J. Bateman},
  booktitle={PloS one},
Apolipoprotein E (ApoE) is the strongest genetic risk factor for Alzheimer's disease and has been implicated in the risk for other neurological disorders. The three common ApoE isoforms (ApoE2, E3, and E4) each differ by a single amino acid, with ApoE4 increasing and ApoE2 decreasing the risk of Alzheimer's disease (AD). Both the isoform and amount of ApoE in the brain modulate AD pathology by altering the extent of amyloid beta (Aβ) peptide deposition. Therefore, quantifying ApoE isoform… CONTINUE READING
Highly Cited
This paper has 231 citations. REVIEW CITATIONS
13 Citations
55 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 13 extracted citations

231 Citations

Citations per Year
Semantic Scholar estimates that this publication has 231 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 55 references

Similar Papers

Loading similar papers…