In Vivo Formation of Ethinylestradiol After Intramuscular Administration of Norethisterone Enantate

@article{Friedrich2018InVF,
  title={In Vivo Formation of Ethinylestradiol After Intramuscular Administration of Norethisterone Enantate},
  author={Christian Friedrich and Matthias Berse and Stefan Klein and Beate Rohde and Joachim H{\"o}chel},
  journal={The Journal of Clinical Pharmacology},
  year={2018},
  volume={58}
}
It is known that a small fraction of orally administered norethisterone is metabolically converted to ethinylestradiol. This exploratory, open‐label, nonrandomized study was conducted to investigate the systemic exposure to ethinylestradiol after intramuscular administration of norethisterone enantate in comparison with the exposure to ethinylestradiol after administration of a standard combined oral contraceptive. Sixteen healthy premenopausal women received an oral contraceptive… Expand
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