In Vivo Fatty Acid Incorporation into Brain Phospholipids in Relation to Signal Transduction and Membrane Remodeling

@article{Rapoport1999InVF,
  title={In Vivo Fatty Acid Incorporation into Brain Phospholipids in Relation to Signal Transduction and Membrane Remodeling},
  author={Stanley I. Rapoport},
  journal={Neurochemical Research},
  year={1999},
  volume={24},
  pages={1403-1415}
}
A method and model are described to quantify in vivo turnover rates and half-lives of fatty acids within brain phospholipids. These “kinetic” parameters can be calculated by operational equations from measured rates of incorporation of intravenously injected fatty acid radiotracers into brain phospholipids. To do this, it is necessary to determine a “dilution factor” λ, which estimates the contribution to the brain precursor acyl-CoA pool of fatty acids released from phospholipids through the… CONTINUE READING

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In vivo brain imaging of signal trans- duction using [11C]arachidonic acid and positron emission tomography

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