In Vivo Evaluation of Doxorubicin-Loaded (PEG)3-PLA Nanopolymersomes (PolyDoxSome) Using DMBA-Induced Mammary Carcinoma Rat Model and Comparison with Marketed LipoDox™

@article{Ayen2012InVE,
  title={In Vivo Evaluation of Doxorubicin-Loaded (PEG)3-PLA Nanopolymersomes (PolyDoxSome) Using DMBA-Induced Mammary Carcinoma Rat Model and Comparison with Marketed LipoDox{\texttrademark}},
  author={Wubeante Yenet Ayen and Neeraj Kumar},
  journal={Pharmaceutical Research},
  year={2012},
  volume={29},
  pages={2522-2533}
}
AbstractPurposeTo evaluate in vivo doxorubicin-loaded (PEG)3-PLA nanopolymersomes (PolyDoxSome) using 7,12-dimethyl benz[α]anthracene (DMBA)-induced mammary carcinoma rat model compared to marketed formulation LipoDox™.MethodsSprague Dawley female rats with mean tumor volume of about 2 cm3 were used for pharmacokinetics, biodistribution, antitumor efficacy and toxicity studies.ResultsThis study demonstrates that PolyDoxSome has higher AUC (569 vs. 4 h*μg/mL), longer plasma circulation half life… 
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