In Vivo Evaluation of Doxorubicin-Loaded (PEG)3-PLA Nanopolymersomes (PolyDoxSome) Using DMBA-Induced Mammary Carcinoma Rat Model and Comparison with Marketed LipoDox™

  title={In Vivo Evaluation of Doxorubicin-Loaded (PEG)3-PLA Nanopolymersomes (PolyDoxSome) Using DMBA-Induced Mammary Carcinoma Rat Model and Comparison with Marketed LipoDox{\texttrademark}},
  author={Wubeante Yenet Ayen and Neeraj Kumar},
  journal={Pharmaceutical Research},
AbstractPurposeTo evaluate in vivo doxorubicin-loaded (PEG)3-PLA nanopolymersomes (PolyDoxSome) using 7,12-dimethyl benz[α]anthracene (DMBA)-induced mammary carcinoma rat model compared to marketed formulation LipoDox™.MethodsSprague Dawley female rats with mean tumor volume of about 2 cm3 were used for pharmacokinetics, biodistribution, antitumor efficacy and toxicity studies.ResultsThis study demonstrates that PolyDoxSome has higher AUC (569 vs. 4 h*μg/mL), longer plasma circulation half life… 
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PolyDoxSome was able to control the release of doxorubicin in pH dependent manner and effectively deliver the drug in active form to MCF-7 breast cancer cells and showed a better cytotoxicity ofDoxorubsin at equivalent dose in nanopolymersomes.
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The results of this study are consistent with preclinical findings indicating that the pharmacokinetics of doxorubicin are drastically altered using Doxil and follow a pattern dictated by the liposome carrier.
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Both DP and EP nanoparticles greatly reduced the distribution of Dox to heart both after i.v. and i.p. injection, suggesting their potential in reducing Dox-associated cardiotoxicity.
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PAMBO formulation is found to be more efficacious and less toxic in a fungal mice model and shows better dose to dose efficacy as compared to Fungizone.