In Vivo Effect of Wood Smoke on the Expression of Two Mucin Genes in Rat Airways

@article{Bhattacharyya2004InVE,
  title={In Vivo Effect of Wood Smoke on the Expression of Two Mucin Genes in Rat Airways},
  author={Sambhu N. Bhattacharyya and Michael A. Dubick and Loudon D. Yantis and John I. Enriquez and Kelvin C. Buchanan and Surinder K Batra and Rebecca A. Smiley},
  journal={Inflammation},
  year={2004},
  volume={28},
  pages={67-76}
}
A short-term, time-dependent smoke exposure of rats in a nose-only chamber to burning wood and 24-h recovery time revealed inflammation of the airways with varying degrees of injury from loss of cilia, degeneration of epithelium, and squamous metaplasia to submucosal edema. These histological changes were reflected in variable expression of the secretory Muc5AC and low expression of membrane-associated Muc4 mucin genes. 20-min smoke exposure in extended recovery experiments showed marked… CONTINUE READING
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