In Vivo Effect of Wood Smoke on the Expression of Two Mucin Genes in Rat Airways

  title={In Vivo Effect of Wood Smoke on the Expression of Two Mucin Genes in Rat Airways},
  author={Sambhu N. Bhattacharyya and Michael A. Dubick and Loudon D. Yantis and John I. Enriquez and Kelvin C. Buchanan and Surinder K Batra and Rebecca A. Smiley},
A short-term, time-dependent smoke exposure of rats in a nose-only chamber to burning wood and 24-h recovery time revealed inflammation of the airways with varying degrees of injury from loss of cilia, degeneration of epithelium, and squamous metaplasia to submucosal edema. These histological changes were reflected in variable expression of the secretory Muc5AC and low expression of membrane-associated Muc4 mucin genes. 20-min smoke exposure in extended recovery experiments showed marked… CONTINUE READING

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Publications referenced by this paper.

In:Further Development of a Test Method for the Assessment of the Acute Inhalation Toxicity of Combustion Products

  • B. S. Levin, A. J. Fowell, M. M. Birky, M. Paabo, A. Stolte, D. Malek
  • National Bureau of Standards (publication 82–2532…
  • 1982
Highly Influential
6 Excerpts

Acroleininduced MUC5AC in rat

  • M. T. Borchers, S. E. Wert, G. D. Lleikauf
  • airways. Am. J. Physiol. 18:L573–L581
  • 1998
1 Excerpt

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