In Vivo Effect and Parallel in Vitro Lymphocyte-mediated Tumor Cytolysis after Phase I Xenogeneic Immune RNA Treatment of Patients with Widespread Melanoma or Metastatic Renal Cell Carcinoma 1

Seven patients with metastatic renal cell carcinoma or wide spread melanoma were included in a Phase I clinical trial of xenogeneic immune RNA (I-RNA). I-RNA, extracted from the lymphoid tissues of guinea pigs immunized with the patient's primary tumor, was incubated in vitro with autologous lympho cytes harvested by leukapheresis. Each patient received… CONTINUE READING