In Vivo Determination of Direct Targets of the Nonsense-Mediated Decay Pathway in Drosophila

@inproceedings{Chapin2014InVD,
  title={In Vivo Determination of Direct Targets of the Nonsense-Mediated Decay Pathway in Drosophila},
  author={Alex Chapin and Hao Hu and Shawn Rynearson and Julie Hollien and Mark Yandell and Mark M Metzstein},
  booktitle={G3},
  year={2014}
}
Nonsense-mediated messenger RNA (mRNA) decay (NMD) is a mRNA degradation pathway that regulates a significant portion of the transcriptome. The expression levels of numerous genes are known to be altered in NMD mutants, but it is not known which of these transcripts is a direct pathway target. Here, we present the first genome-wide analysis of direct NMD targeting in an intact animal. By using rapid reactivation of the NMD pathway in a Drosophila melanogaster NMD mutant and globally monitoring… CONTINUE READING
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