In Vivo Detection of HSP90 Identifies Breast Cancers with Aggressive Behavior.

@article{Osada2017InVD,
  title={In Vivo Detection of HSP90 Identifies Breast Cancers with Aggressive Behavior.},
  author={Takuya Osada and Kensuke Kaneko and William R Gwin and Michael Andew Morse and Amy C. Hobeika and Brian W. Pogue and Zachary C. Hartman and Philip F Hughes and Timothy A. J. Haystead and Herbert Kim Lyerly},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2017},
  volume={23 24},
  pages={7531-7542}
}
Purpose: Hsp90, a chaperone to numerous molecular pathways in malignant cells, is elevated in aggressive breast cancers. We hypothesized that identifying breast cells with elevated Hsp90 activity in situ could result in early detection of aggressive breast cancers.Experimental Design: We exploited the uptake of an Hsp90 inhibitor by malignant cells to… CONTINUE READING