In Vivo Detection of Age- and Disease-Related Increases in Neuroinflammation by 18F-GE180 TSPO MicroPET Imaging in Wild-Type and Alzheimer's Transgenic Mice.

@article{Liu2015InVD,
  title={In Vivo Detection of Age- and Disease-Related Increases in Neuroinflammation by 18F-GE180 TSPO MicroPET Imaging in Wild-Type and Alzheimer's Transgenic Mice.},
  author={Bin Liu and Kevin X Le and Mi-Ae Park and Shuyan Wang and Anthony P Belanger and Shipra Dubey and Jeffrey L. Frost and Peter Holton and Vladim{\'i}r Reiser and Paul A Jones and William Trigg and Marcelo Di Carli and Cynthia A Lemere},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2015},
  volume={35 47},
  pages={15716-30}
}
UNLABELLED Alzheimer's disease (AD) is the most common cause of dementia. Neuroinflammation appears to play an important role in AD pathogenesis. Ligands of the 18 kDa translocator protein (TSPO), a marker for activated microglia, have been used as positron emission tomography (PET) tracers to reflect neuroinflammation in humans and mouse models. Here, we used the novel TSPO-targeted PET tracer (18)F-GE180 (flutriciclamide) to investigate differences in neuroinflammation between young and old… CONTINUE READING
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