In Vivo Coupling of Cell Elongation and Lumen Formation in a Single Cell

@article{Gervais2010InVC,
  title={In Vivo Coupling of Cell Elongation and Lumen Formation in a Single Cell},
  author={Louis Gervais and Jordi Casanova},
  journal={Current Biology},
  year={2010},
  volume={20},
  pages={359-366}
}
Fine tubes form inside cells as they reach their target tissues in epithelial ducts and in angiogenesis. Although a very suggestive model of cell hollowing proposes that intracellular lumen could arise by coalescence of intracellular vacuoles, how those tubes form in vivo remains an open question. We addressed this issue by examining intracellular lumen formation in the Drosophila trachea. The main branches of the Drosophila tracheal system have an extracellular lumen because their cells fold… CONTINUE READING

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